Antwort: 

von Lisa4dict loggedout, 2014-06-14, 14:09   Spam?  99.11.162....

... for a system.
for a person "auf den Beinen," "geschäftig/busy"  etc.

Antwort: 

von Ehoeh, 2014-06-14, 18:15   Spam?  78.41.149....

It's nice to see you up and running again. (i.e. that you have recovered) = Schön, dass du wieder ganz auf den Beinen bist.

"Es läuft." would be "Things are going pretty well"

Antwort: 

von Lisa4dict loggedout, 2014-06-14, 18:21   Spam?  99.11.162....

You can say of a machine or a system, "Es läuft (...)." and mean it's up and running.  The up part is implied in this case since it has to be up to be running.

Antwort: 

von Ehoeh, 2014-06-14, 18:35   Spam?  78.41.149....

I don't quite agree that the "up" part is implied. It adds further meaning and corresponds to "Das System läuft (jetzt) wieder" in German.

Antwort: 

von Lisa4dict loggedout, 2014-06-14, 18:42   Spam?  99.11.162....

up and running doesn't have to be "wieder."  It can mean it's been started up for the first time and is running.  If you wanted a wordy German equivalent you could say: das System/ die Maschine ist hochgefahren und läuft.

Antwort: 

von Ehoeh, 2014-06-14, 19:26   Spam?  78.41.149....

As usual, it all depends on the context. As theTargGuy did not mention any system or machine you can't possible argue "not the way it's used here".

Antwort: 

von atemp (US), Last modified: 2014-06-14, 23:17   Spam?  

Applying up and running is a little bit odd when speaking to a living being, rather than to a robot. Nevertheless it is done, but It's nice to see you up and running again has a few subtexts as well:

1) Implies that the person was till recently in ill health or indisposed.
2) Implies cheerful approval and high regard by the speaker for the person.
3) The again is used to terminate the central statement; it is optional, but works well here because it does suggest that running, i.e. working well at peak efficiency or in best health, is good and desirable.

Chat:     

von Lisa4dict loggedout, 2014-06-15, 06:02   Spam?  99.11.162....

can't possible argue "not the way it's used here"  Didn't mean "used in this instance" but rather "the way people use the expression - when referring to machinery and systems - in this area of the world does not carry any limitation to it being 'running again' as you implied."